Special Colloquium

Event Information Understanding Kidney Physiology: A Modeling Approach
14:10 on Friday March 24, 2017
15:00 on Friday March 24, 2017
BA1210, Bahen Center, 40 St. George St.
Anita Layton
Duke University

The kidney not only filters metabolic wastes and toxins from the body, it also regulates the body's water balance, electrolyte balance, and acid-base balance, blood pressure, and blood flow. Despite intense research, aspects of kidney functions remain incompletely understood. I will discuss how our group use mathematical analysis and modeling techniques to address a host of previously unanswered questions in renal physiology and pathophysiology: Why is the mammalian kidney so susceptible to hypoxia, despite receiving ~25% of the cardiac output? What are the mechanisms underlying the development of acute kidney injury in a patient who has undergone cardiac surgery performed on cardiopulmonary bypass? How is renal blood flow affected by the interactions between negative and positive feedback mechanisms?